Pengaruh Pemberian Mesenchymal Stem Cells Wharton's Jelly terhadap Ekspresi Gen Sirtuin 1 pada Tikus Model Alzheimer

Mesenchymal Stem Cells Wharton's Jelly (MSC-WJ) has become a new hope for Alzheimer's disease due to its capability suppress Amyloid-beta (Aβ) plaques formation. It is found that people with have lower expression of Sirtuin-1 because the oxidative stress was produced by Aβ plaques. Objective: To observe gene in rat models AlCl3 inducing after being given MSC-WJ. Methods: This an experimental study post-test-only control group design, including three groups total sample 18 samples Alzheimer RNA models. Group-1without and MSC-WJ; Group-2 AlCl3; Group-3 Mean value obtained Image-J application using semiquantitative method which then tested One Way ANOVA test. The significant if p-value < 0,05. Results: mean ± standard error were 0.18±0.04; 0.16±0.03; 0.36±0.06 respectively. statistical test showed difference between (p = 0.014). Conclusion: There increased Sirtuin 1 Alzheimer’s Model Wharton’s Jelly.Keywords: Alzheimer, MSC-WJ,